8.51090

TFFH

Tetramethylfluoroformamidinium hexafluorophosphate Novabiochem^®

• Synonym(e): TFFH, Tetramethylfluoroformamidinium hexafluorophosphate,Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate
• Empirische Formel (Hill-System): C₅H₁₂F₇N₂P
• CAS-Nummer: 164298-23-1
• Molekulargewicht: 264.12
• UNSPSC Code: 12352107
• NACRES: NA.22
• MDL number: MFCD02684443
• Form: solid

Eigenschaften

• Quality Segment: 200
• product line: Novabiochem^®
• form: solid
• reaction suitability: reaction type: Coupling Reactions
• manufacturer/tradename: Novabiochem^®
• mp: 104-109 °C
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: FC(=[N+](C)C)N(C)C
• InChI: 1S/C5H12FN2/c1-7(2)5(6)8(3)4/h1-4H3/q+1
• InChI key: JILUGXGJYPRQPA-UHFFFAOYSA-N

Beschreibung

General description

TFFH is an in situ coupling reagents which smoothly converts protected amino acids to the corresponding acid fluoride in the presence of base ^[1]. Acid fluorides have proven are highly effective at coupling hindered amino acids such as α,α-disubstituted amino acids ^[2].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] L. A. Carpino, et al. (1995) J. Am. Chem. Soc., 117, 5401.
^[2] S. A. Triolo, et al. in ′Peptides 1996, Proc. of 24th European Peptide Symposium′, R. Ramage & R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1998, pp. 839.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay 1H-qNMR: ≥ 98.0 %
Ratio Cation/anion in 19F-NMR integration: lot specific result
1:5,7 to 1:6,3
Identity (IR): passes test

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H315,H318,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable