8.51088

TOTU

Novabiochem^®

• Synonym(e): TOTU, O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,NÆ,NÆ-tetramethyluronium tetrafluoroborate
• Empirische Formel (Hill-System): C₁₀H₁₇BF₄N₄O₃
• CAS-Nummer: 136849-72-4
• Molekulargewicht: 328.07
• UNSPSC Code: 12352116
• NACRES: NA.22
• MDL number: MFCD00192127
• Assay: ≥99.0% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 200
• product line: Novabiochem^®
• assay: ≥99.0% (HPLC)
• form: powder
• potency: 500-650 mg/kg LD₅₀, oral (Rat)
• reaction suitability: reaction type: Coupling Reactions
• manufacturer/tradename: Novabiochem^®
• mp: 142-148 °C
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: [B-](F)(F)(F)F.N([C+](N(C)C)ON=C(C(=O)OCC)C#N)(C)C
• InChI: 1S/C10H17N4O3.BF4/c1-6-16-9(15)8(7-11)12-17-10(13(2)3)14(4)5;2-1(3,4)5/h6H2,1-5H3;/q+1;-1
• InChI key: FPQVGDGSRVMNMR-UHFFFAOYSA-N

Beschreibung

General description

TOTU is an excellent alternative to HOBt-based coupling reagents such as HBTU and TBTU. It has high reactivity and is likely to have low allergenicity and low explosivity. The by-products of using this coupling reagent are water-soluble, making it an ideal choice for solution phase coupling reactions.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents


Literature references

^[1] G. Breipohl & W. Koenig, US patent 5166394.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): conforms
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clear soluble

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• pictograms: GHS05,GHS07
• signalword: Danger
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1A - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• hcodes: H302,H317,H318,H335