555580

Ribavirin

A non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.

• Synonym(e): Ribavirin, 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole
• Empirische Formel (Hill-System): C₈H₁₂N₄O₅
• CAS-Nummer: 36791-04-5
• Molekulargewicht: 244.20
• MDL-Nummer: MFCD00058564
• UNSPSC-Code: 41116107

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥99% (HPLC); ≥99% (TLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Farbe: white
• Löslichkeit: water: 20 mg/mL; DMSO: soluble
• Versandbedingung: ambient
• Lagertemp.: 15-25°C
• InChI: 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
• InChIKey: IWUCXVSUMQZMFG-AFCXAGJDSA-N

Beschreibung

Allgemeine Beschreibung

A non-interferon-inducing, broad spectrum antiviral nucleoside that is active against RSV, HIV, HCV and other infectious agents. Inhibits the growth of human myeloma 8226 cells (IC₅₀ = 40 µM) and ovarian carcinoma OVCAR-5 cells (IC₅₀ = 35 µM). Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase. Antiviral effects of Ribavirin can be reversed by depriving infected cells of methionine or isoleucine.

A non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.

Warnhinweis

Toxicity: Carcinogenic / Teratogenic (D)

Sonstige Hinweise

Li, W., et al. 1999. Oncol. Res.11, 243.
Honda, Y., et al. 1994. Antimicrob. Agents Chemother.38, 653.
Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.
Kakumu, S., et al. 1993. Gastroenterology105, 507.
Sidwell, R.W., et al. 1979. Pharmacol. Ther.6, 123.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H341,H360FD
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Muta. 2 - Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable