5.05873

(R)-Baclofen

• Synonym(e): (R)-Baclofen, STX 209, GABA _B Agonist, Baclofen, Arbaclofen, STX 209, GABA_B Agonist, Baclofen, Arbaclofen
• Empirische Formel (Hill-System): C₁₀H₁₂ClNO₂
• CAS-Nummer: 69308-37-8
• Molekulargewicht: 213.66
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: water: soluble
• storage temp.: 2-8°C
• InChI: 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
• InChI key: KPYSYYIEGFHWSV-UHFFFAOYSA-N

Beschreibung

General description

A selective agonist of GABA_B receptors that is shown to activate K+ conductance in hippocampal neurons. Also acts as an antispastic agent and a skeletal muscle relaxant. It is also an experimental drug to treat autism.

Biochem/physiol Actions

Primary Target
GABA_B

Preparation Note

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Sodickson, D.L., et al., 1996. J. Neurosci.16, 6374.

Ahuja, S. et al., 1985. Analytical Profile of Drug Substances14, 527.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects