444247

MMP-Inhibitor II

The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(e): MMP-Inhibitor II, N-Hydroxy-1,3-di-(4-methoxybenzolsulfonyl)-5,5-dimethyl-[1,3]-piperazin-2-carboxamid
• Empirische Formel (Hill-System): C₂₁H₂₇N₃O₈S₂
• CAS-Nummer: 203915-59-7
• Molekulargewicht: 513.58
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C21H27N3O8S2/c1-21(2)13-23(33(27,28)17-9-5-15(31-3)6-10-17)20(19(25)22-26)24(14-21)34(29,30)18-11-7-16(32-4)8-12-18/h5-12,20,26H,13-14H2,1-4H3,(H,22,25)
• InChI key: MCSWSPNUKWMZHM-UHFFFAOYSA-N

Beschreibung

General description

Ein potenter, nicht reversibler Inhibitor von Matrix-Metalloproteinasen. Hemmt MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18,4 nM), MMP-7 (IC₅₀ = 30 nM) und MMP-9 (IC₅₀ = 2,7 nM).

Ein potenter, reversibler Breitband-Inhibitor von Matrix-Metalloproteinasen. Hemmt MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18,4 nM), MMP-7 (IC₅₀ = 30 nM) und MMP-9 (IC₅₀ = 2,7 nM).

Biochem/physiol Actions

Produkt konkurriert nicht mit ATP.

Reversibel: ja

Zellpermeabel: ja

Ziel-IC₅₀: 24 nM, 18,4 nM, 30 nM, 2,7 nM, jeweils gegen MMP-1, MMP-3, MMp-7 und MMP-9

Packaging

Verpackt unter inertem Gas

Preparation Note

Erfordert kräftiges Schütteln für 60 Sekunden, um das Produkt vollständig zu lösen.

Other Notes

Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxizität: Standard-Handhabung (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable