371545

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP.

• Synonym(e): Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem, GTPγ-S, 4Li
• Empirische Formel (Hill-System): C₁₀H₁₂N₅O₁₃P₃S · 4Li
• CAS-Nummer: 94825-44-2
• Molekulargewicht: 562.98
• UNSPSC Code: 12352200
• MDL number: MFCD00135151

Eigenschaften

• assay: ≥85% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• impurities: ≤12% GDP
• color: white
• solubility: water: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Beschreibung

General description

G-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P₃ formation in membranes.

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
G-protein-activating GTP analog

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.

Other Notes

Iino, S., et al. 2000. FEBS Lett.479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem.267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci.49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol.422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem.264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem.56, 615.
Orellana, S., et al. 1987. J. Biol. Chem..262, 1638.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable