342000

Caspase Inhibitor, Negative Control

The Caspase Inhibitor, Negative Control, also referenced under CAS 105637-38-5, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(e): Caspase Inhibitor, Negative Control, Z-FA-FMK, Cathepsin B, Inhibitor I
• Empirische Formel (Hill-System): C₂₁H₂₃FN₂O₄
• CAS-Nummer: 105637-38-5
• Molekulargewicht: 386.42
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: off-white
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)
• InChI key: ASXVEBPEZMSPHB-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Cathepsin-B

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Schotte, P., et al. 2001. J. Biol. Chem.276, 21153.
Guo, H., et al. 1998. Exp. Cell Res.245, 57.
Rosenthal, P.J., et al. 1993. J. Clin. Invest.91, 1057.
Ahmed, N.K., et al. 1992. Biochem. Pharmacol.44, 1201.
Rauber, P., et al. 1986. Biochem. J. 239, 633.
Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
Rasnick, D. 1985. Anal. Biochem. 149, 461.

Z-Phe-Ala-FMK

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable