251406

3-Methylpyrazol-5-Carboxylsäure

AS057278

• Synonym(e): 3-Methylpyrazole-5-carboxylic acid, 5-Methylpyrazole-3-carboxylic acid, AS057278, MPC
• Empirische Formel (Hill-System): C₅H₆N₂O₂
• CAS-Nummer: 402-61-9
• Molekulargewicht: 126.11
• UNSPSC Code: 12352100
• NACRES: NA.28
• MDL number: MFCD00462235
• Form: white solid
• Storage condition: OK to freeze

Eigenschaften

• Quality Segment: 100
• form: white solid
• storage condition: OK to freeze
• mp: 236-240 °C (lit.)
• solubility: soluble (DMSO (50 mg/ml))
• storage temp.: 2-8°C
• SMILES string: Cc1cc([nH]n1)C(O)=O
• InChI: 1S/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9)
• InChI key: WSMQKESQZFQMFW-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910 nM against human DAO; [D-ser] = 10 mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50 mM) exposure (ED50 ≤3.95 µM), while exhibiting little affinity toward NMDAR glycine binding site (6% inhibition at 100 µM), nor inhibitory activity against D-aspartate oxidase (DDO/DSOX; 43% inhibition at 100 µM) or serine racemase (no inhibition at 50 µM). AS057278 is orally available (plasma Cmax = 8.089 µg/mL; t1/2 = 7.21 h; tmax = 1 h post 10 mg/mL oral dosing in rats) and can cross blood-brain barrier (1.622 and 0.578 µg/g brain tissue, respectively, 15 and 60 min post single 10 mg/kg i.v. dosing in rats). Effectively prevents PCP (phencyclidine) from suppressing PPI (prepulse inhibition; prepulse noise = 82 dB, startle noise = 120 dB) response in mice via either long-term oral administration (93% and 70% of no-PCP control PPI level, respectively, with or without 28-day b.i.d, treatment at 20 mg/kg/12 h) or single acute heavy oral dosing (93% and 53% of no-PCP control PPI level, respectively, with or without 80 mg/kg dosing) 60 min prior to PCP treatment (8 mg/kg i.p.) in vivo.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable