23-056-M

XIAP, active

• Synonym(e): Baculoviral IAP repeat-containing protein 4 (BIRC4), IAP-like protein, Inhibitor of apoptosis protein 3 (API3)
• UNSPSC Code: 12352204
• NACRES: NA.41
• eCl@ss: 32160405
• Biological source: human

Eigenschaften

• biological source: human
• Quality Segment: 100
• form: liquid
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable
• NCBI accession no.: NM_001167

Beschreibung

General description

X-linked inhibitor of apoptosis (XIAP) is one of a group of intracellular proteins which have been shown to act as endogenous inhibitors of caspases, the enzymatic effectors of apoptosis. XIAP possesses a C-terminal RING domain that functions as an E3 ubiquitin ligase and is able to ubiquitinate a variety of substrates thereby affecting a broad range of cellular activities beyond apoptotic suppression. There is evidence that XIAP plays a significant role in cell division, morphogenesis, heavy metal homeostasis, NF-kB activation and MAP kinase signalling. XIAP expression has been shown to be elevated in several malignancies and so is considered a promising target in anticancer therapies.

Application

Ubiquitination Cascade Comoponent: E3

Physical form

Purified using glutathione sepharose, followed by gel filtration

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable