07-436-AF488

Anti-monomethyl Histone H3 (Lys4) Antibody, Alexa Fluor^™ 488 Conjugate

0.5 mg/mL, from rabbit

• Synonym(e): Histone H3.1t, H3/t, H3t, H3/g
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: ALEXA FLUOR^™ 488
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Speziesreaktivität: human
• Speziesreaktivität (Voraussage durch Homologie): vertebrates (based on 100% sequence homology)
• Konzentration: 0.5 mg/mL
• Methode(n): immunocytochemistry: suitable
• NCBI-Hinterlegungsnummer: NM_003493
• UniProt-Hinterlegungsnummer: Q16695
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: monomethylation (Lys4)
• Angaben zum Gen: human ... H3C1(8350)

Beschreibung

Allgemeine Beschreibung

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 07-436.

Immunogen

Linear peptide corresponding to Histone H3 monomethylated at Lys4.

Anwendung

This Anti-monomethyl Histone H3 (Lys4) Antibody, Alexa Fluor^™ 488 Conjugate is validated for use in ICC for the detection of monomethyl Histone H3 (Lys4).

Qualität

Evaluated by Immunocytochemisty Analysis in HeLa cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected monomethyl Histone H3 (Lys4) in HeLa cells.

Alexa Fluor^™ is a registered trademark of Life Technologies.

Zielbeschreibung

~17 kDa observed (Refer to Cat. No. 07-436)

Physikalische Form

Purified rabbit Alexa Fluor^™ 488 conjugated antibody in buffer containing PBS with 15 mg/ml BSA and 0.1% Sodium Azide.

Rechtliche Hinweise

ALEXA FLUOR is a trademark of Life Technologies

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable