03-0187-00

SMC^® Human MCP-1 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human MCP-1 in human serum and plasma

• Synonym(e): MCP 1 immunoassay kit, MCP-1 Single Molecule Counting Kit, MCP-1 ultra-sensitive immunoassay, Monocyte Chemoattractant Protein-1 immunoassay kit
• NACRES: NA.84
• UNSPSC Code: 12161503
• Species reactivity: human
• Technique(s): single molecule counting: suitable
• Usage: kit sufficient for 96 wells
• Compatibility: for use with FemtoQuest^™ and SMCxPRO^® instruments

Eigenschaften

• Produktname: SMC^® Human MCP-1 High Sensitivity Immunoassay Kit,
• description: Used for ultrasensitive quantification of Human MCP-1 in human serum and plasma
• product line: SMC^®
• usage: kit sufficient for 96 wells
• species reactivity: human
• technique(s): single molecule counting: suitable
• input: plasma (K2 EDTA); serum
• UniProt accession no.: P13500
• compatibility: for use with FemtoQuest^™ and SMCxPRO^® instruments
• shipped in: wet ice
• storage temp.: 2-8°C

Beschreibung

General description

Monocyte Chemoattractant Protein-1 (MCP-1), also known as CCL2, is a chemokine that plays a critical role in the recruitment of monocytes to sites of inflammation and injury. It is produced by various cell types, including macrophages, endothelial cells, and fibroblasts, in response to inflammatory stimuli. MCP-1 is involved in several physiological and pathological processes, including atherosclerosis, chronic inflammatory diseases, and tissue repair.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease

Features and Benefits

• Breakthrough-level sensitivity for translational research: Supports early-stage biomarker identification and immune profiling with unmatched precision.
• Wide Quantification Range: Captures MCP-1 levels across both baseline and elevated inflammatory states, ideal for diverse sample types.
• Streamlined ELISA Workflow with SMC^® Enhancements: Uses a familiar sandwich immunoassay format with a unique elution step for digital molecule counting.
• Illuminate Monocyte Migration Pathways: MCP-1 is a key chemokine in immune cell recruitment; this kit helps quantify its role in inflammation and tissue infiltration.

Packaging

96 well assay

Analysis Note

• Sensitivity: LLOQ 150 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 80-400,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 102% Plasma: 94%
• Recovery: Serum: 104% Plasma: 101%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

MCP-1 was not cross-reactive with rat, mouse, or canine samples.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• hcodes: H302 + H332,H311,H319,H360FD,H412,EUH430
• pcodes: P201 - P202 - P273 - P280 - P308 + P313 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B