INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
Synonyme:
CORS1, CPD4, JBTS1, MORMS, PPI5PIV
Spezies:
Human INPP5E (56623), Mouse Inpp5e (64436), Rat Inpp5e (114089), naked mole-rat Inpp5e (101701719), sheep INPP5E (101115530), dog INPP5E (607443), domestic guinea pig Inpp5e (100715053), chicken INPP5E (417135), domestic cat INPP5E (101093901), Zebrafish inpp5e (606579)
UniProtKB-ID:
Gen-ID:
- Human(56623) Summary: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011]
- Mouse(64436) inositol polyphosphate-5-phosphatase E
- Rat(114089) inositol polyphosphate-5-phosphatase E
- naked mole-rat(101701719) inositol polyphosphate-5-phosphatase, 72 kDa
- sheep(101115530) inositol polyphosphate-5-phosphatase, 72 kDa
- dog(607443) inositol polyphosphate-5-phosphatase, 72 kDa
- domestic guinea pig(100715053) inositol polyphosphate-5-phosphatase, 72 kDa
- chicken(417135) inositol polyphosphate-5-phosphatase, 72 kDa
- domestic cat(101093901) inositol polyphosphate-5-phosphatase, 72 kDa
- Zebrafish(606579) inositol polyphosphate-5-phosphatase
- cow(506349) inositol polyphosphate-5-phosphatase, 72 kDa
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-INPP5E antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Anti-INPP5E antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
western blot