Biotransformation of 1,4-cineole, a monoterpene ether.

Biotransformation of 1,4-cineole, a monoterpene ether.

Xenobiotica; the fate of foreign compounds in biological systems (1988-10-01)

Y Asakawa, M Toyota, T Ishida

ABSTRACT

1. The metabolism of 1,4-cineole, a monoterpene ether, was studied in the rabbit. 2. Four neutral and one acidic metabolites were isolated from the urine and shown to be 9-hydroxy-1,4-cineole, 3,8-dihydroxy-1,4-cineole, 8,9-dihydroxy-1,4-cineole, 1,4-cineole-8-en-9-ol and 1,4-cineole-9-carboxylic acid.

MATERIALS

Product Number

Brand

Product Description

27395

Sigma-Aldrich

1,4-Cineole, technical, mixture of isomers, ≥85% (GC)

27393

Supelco

1,4-Cineole, analytical standard