1082708

Butylated hydroxytoluene

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC
• Linear Formula: [(CH₃)₃C]₂C₆H₂(CH₃)OH
• CAS Number: 128-37-0
• Molecular Weight: 220.35
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329749182
• EC Number: 204-881-4
• Beilstein/REAXYS Number: 1911640
• MDL number: MFCD00011644

Properties

• grade: pharmaceutical primary standard
• agency: USP
• vapor density: 7.6 (vs air)
• vapor pressure: <0.01 mmHg ( 20 °C)
• API family: butylated hydroxytoluene
• form: crystalline powder
• autoignition temp.: 878 °F
• manufacturer/tradename: USP
• bp: 265 °C (lit.)
• mp: 69-73 °C (lit.)
• application(s): USP Biologics; pharmaceutical (small molecule)
• format: neat
• SMILES string: Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
• InChI: 1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
• InChI key: NLZUEZXRPGMBCV-UHFFFAOYSA-N

Description

General description

Butylated hydroxytoluene (BHT) is a synthetic antioxidant commonly used in biologic formulations to prevent oxidative degradation. It acts as a preservative, protecting biologic products from oxidation, which can affect the potency and stability of sensitive molecules. Its application is critical in maintaining the integrity of biologics, particularly those that are exposed to air or light during production and storage.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Butylated hydroxytoluene USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Dutasteride and Tamsulosin Hydrochloride Capsules

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Sales restrictions may apply.

This product is part of USP Biologics Program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Ph

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P391 - P501
• Storage Class: 11 - Combustible Solids
• flash_point_f: 260.6 °F - open cup
• flash_point_c: 127 °C - open cup
• Hazard Classifications: Aquatic Chronic 1