1045009

Atropine sulfate

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Atropine sulfate salt monohydrate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate
• Linear Formula: (C₁₇H₂₃NO₃)₂ · H₂SO₄ · H₂O
• CAS Number: 5908-99-6
• Molecular Weight: 694.83
• Beilstein: 6109275
• MDL number: MFCD00074815
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749082
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: atropine
• manufacturer/tradename: USP
• mp: 189-192 °C (A) (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6
• InChI: 1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
• InChI key: JPKKQJKQTPNWTR-CHYDPLAESA-N
• Gene Information: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Atropine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Atropine Sulfate Injection
• Atropine Sulfate Ophthalmic Solution
• Atropine Sulfate Ophthalmic Ointment
• Diphenoxylate Hydrochloride and Atropine Sulfate Tablets
• Diphenoxylate Hydrochloride and Atropine Sulfate Oral Solution
• Atropine

Biochem/physiol Actions

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300 + H330
• Precautionary Statements: P301 + P310 + P330 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3