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SML3854

Sigma-Aldrich

Potassium clavulanate cellulose (1:1)

≥97% (NMR)

Synonym(s):

(2R,3Z,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium clavulanate cellulose (1:1), Z-(3R,5R)-2-(β-Hydroxyethylidene)clavam-3-carboxylic acid potassium clavulanate cellulose (1:1)

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About This Item

Linear Formula:
(C6H10O5)n
Molecular Weight:
237.25
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥97% (NMR)

form

powder

storage condition

desiccated

color

white to beige

storage temp.

-10 to -25°C

Biochem/physiol Actions

Clavulanic acid is an orally available and potent mechanism-based β-lactamase inhibitor. In combination with β-lactam antibiotic clavulanic acid can overcome antibiotic resistance in bacteria that produce β-lactamase. Clavulanic acid is produced by Streptomyces clavuligerus.

Caution

Hygroscopic

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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In vitro Antibacterial Activity and Resistance Prevention of Antimicrobial Combinations for Dihydropteroate Synthase-Carrying Stenotrophomonas maltophilia
Infection and Drug Resistance, 15, 3039-3046 (2022)
Penicillin-Binding Proteins, ?-Lactamases, and ?-Lactamase Inhibitors in ?-Lactam-Producing Actinobacteria: Self-Resistance Mechanisms
International Journal of Molecular Sciences, 23(10), 5662-5662 (2022)
C Reading et al.
Antimicrobial agents and chemotherapy, 11(5), 852-857 (1977-05-01)
A novel beta-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid. Conditions for the cultivation of the organism and detection and isolation of clavulanic acid are described. This compound resembles the nucleus of

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