SML3424

DIM-C-pPhOH

≥98% (HPLC)

• Synonym(s): 1,1-Bis(3′-indolyl)-1-(p-hydroxyphenyl)methane, 4-(Di-1H-indol-3-ylmethyl)phenol; (4-Hydroxyphenyl)bis(1H-indol-3-yl)methane, 7,7-Bis(3-indolyl)-p-cresol, C-DIM 8, CDIM8
• Empirical Formula (Hill Notation): C₂₃H₁₈N₂O
• CAS Number: 151358-47-3
• Molecular Weight: 338.40
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD03723253
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: off-white to pink
• solubility: DMSO: 2 mg/mL
• storage temp.: −20°C
• SMILES string: OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
• InChI: 1S/C23H18N2O/c26-16-11-9-15(10-12-16)23(19-13-24-21-7-3-1-5-17(19)21)20-14-25-22-8-4-2-6-18(20)22/h1-14,23-26H
• InChI key: QCPDFNWJBQMXLI-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DIM-C-pPhOH is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhOH decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231breast cancer cells. DIM-C-pPhOH inhibits migration of Rh30 and MDA-MB-231 cancer cells.

NR4A1 (Nur77) antagonist that exhibit potent anticancer activity

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable