SML2991

Ru265

≥95% (HPLC), powder, mitochondrial calcium uniporter inhibitor

• Synonym(s): Ru2(μ-N)(NH3)8Cl2]Cl3, trans,trans-Octaamminedichloro-μ-nitridodi-Ruthenium(3+) trichloride, Nitride, ruthenium complex
• Empirical Formula (Hill Notation): Cl₅H₂₄N₉Ru₂
• CAS Number: 27056-01-5
• Molecular Weight: 529.66
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Product Name: Ru265, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to dark beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cl[Ru](N)(N)(N)(N)n[Ru](N)(N)(N)(N)Cl

Description

Biochem/physiol Actions

Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca²⁺] (mCa²⁺), but not cytosolic [Ca²⁺] (cCa²⁺) transient (50 ?M; HeLa) by blocking MCU-mediated mCa²⁺ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa²⁺ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa²⁺ overload.

Selective mitochondrial calcium uniporter (MCU) inhibitor that blocks mitochondrial Ca²⁺ uptake at a >10-fold greater potency as Ru360.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable