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Key Documents

SML2235

Sigma-Aldrich

CL075

≥98% (HPLC)

Synonym(s):

2-Propylthiazolo[4,5-c]quinolin-4-amine, 3M002

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About This Item

Empirical Formula (Hill Notation):
C13H13N3S
CAS Number:
Molecular Weight:
243.33
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c2c(nc1CCC)c(nc3c2cccc3)N

InChI

1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)

InChI key

NFYMGJSUKCDVJR-UHFFFAOYSA-N

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Show Differences

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This Item
SML2566SML0376SML2495
CL075 ≥98% (HPLC)

SML2235

CL075

CL097 ≥98% (HPLC)

SML2566

CL097

CGS 9895 ≥98% (HPLC)

SML0376

CGS 9895

MLS1082 ≥98% (HPLC)

SML2495

MLS1082

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: >2 mg/mL (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to very dark brown

color

light yellow to light brown

color

white to gray-brown

Application

CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.[1]

Biochem/physiol Actions

CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFΚB stimulation in TLR8 compared to 4 μM for TLR7.
CL075 is a thiazoloquinolone derivative[2]. It might influence tumor development.[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Heng Yang et al.
Zhonghua zhong liu za zhi [Chinese journal of oncology], 33(9), 643-648 (2012-02-22)
To observe the expression of Toll-like receptor 8 (TLR8) in human cervical cancer cell-line HeLa cells, and the effects of TLR8 agonist CL075 on the survival and proliferation of HeLa cells. PCR and RT-PCR were used to detect the expression
Cytotoxic activity of human dendritic cells induces RIPK1-dependent cell death
Varga Z, et al.
Immunobiology, 152032-152032 (2020)
Marianne W Mureith et al.
AIDS (London, England), 24(12), 1841-1848 (2010-07-01)
Chronic HIV-1 infection is characterized by high levels of persistent immune activation. Both HIV-1-encoded Toll-like receptor 7/8 (TLR7/8) ligands and TLR ligands encoded by products of microbial translocation have been implicated in inducing and sustaining immune activation in infected individuals

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