SML1769

Cyclotraxin-B trifluoroacetate salt

≥95% (HPLC)

• Synonym(s): CNPMGYTKEGC (Modifications: Disulfide bridge between 1 - 11), L-Cysteinyl-L-asparaginyl-L-prolyl-L-methionylglycyl-L-tyrosyl-L-threonyl-L-lysyl-L-a-glutamylglycyl-L-cysteine, cyclic (1>11)-disulfide
• Empirical Formula (Hill Notation): C₄₈H₇₃N₁₃O₁₇S₃ · xC₂HF₃O₂
• CAS Number: 1203586-72-4
• Molecular Weight: 1200.37 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: film

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: film
• color: colorless
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: S1SC[C@@H](C(=O)N[C@H](C(=O)N2[C@@H](CCC2)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C1)C(=O)O)CCC(=O)O)CCCCN)[C@H](O)C)Cc3ccc(cc3)O)CCSC)CC(=O)N)N
• InChI: 1S/C48H73N13O17S3/c1-24(62)39-46(75)58-28(6-3-4-15-49)43(72)56-29(12-13-38(67)68)41(70)52-21-37(66)55-33(48(77)78)23-81-80-22-27(50)40(69)59-32(19-35(51)64)47(76)61-16-5-7-34(61)45(74)57-30(14-17-79-2)42(71)53-20-36(65)54-31(44(73)60-39)18-25-8-10-26(63)11-9-25/h8-11,24,27-34,39,62-63H,3-7,12-23,49-50H2,1-2H3,(H2,51,64)(H,52,70)(H,53,71)(H,54,65)(H,55,66)(H,56,72)(H,57,74)(H,58,75)(H,59,69)(H,60,73)(H,67,68)(H,77,78)/t24-,27+,28+,29+,30+,31+,32+,33+,34+,39+/m1/s1
• InChI key: JLBMMJHZUYBFGX-ZHTCEXBHSA-N

Description

Biochem/physiol Actions

Cyclotraxin-B is a potent and selective Trk B (BDNF/NT-3) receptor inhibitor.

Cyclotraxin-B is a potent and selective Trk B (BDNF/NT-3) receptor inhibitor. Cyclotraxin-B prevents receptor activation by BDNF without interfering with BDNF binding. Cyclotraxin-B has an IC₅₀ value < 1 nM. In rodent studies Cyclotraxin-B, sometimes fused with tat-protein for increased brain permeability, has been shown to have anxiolytic properties, prevent cold hypersensitivity induced by BDNF, and to reduce cocaine self-administration.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable