SML1707

Temoporfin

≥90% (HPLC)

• Synonym(s): 3,3′,3′′,3′′′-(7,8-Dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-phenol, 5,10,15,20-Tetra(m-hydroxyphenyl)chlorin
• Empirical Formula (Hill Notation): C₄₄H₃₂N₄O₄
• CAS Number: 122341-38-2
• Molecular Weight: 680.75
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥90% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• color: dark brown to black
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• InChI: 1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2
• InChI key: LYPFDBRUNKHDGX-UHFFFAOYSA-N

Description

General description

Temoporfin/(tetra[m-hydroxyphenyl]chlorin, m-THPC), is a hydrophobic second-generation photosensitizer. It is used in the palliative treatment of patients with advanced head and neck cancer by photodynamic therapy.

Biochem/physiol Actions

Temoporfin is a photosensitizer for the photodynamic therapy.

Temoporfin is a photosensitizer for the photodynamic therapy. Temoporfin has been used clinically to treat advanced head and neck squamous cell carcinoma, and is being investigated for use in several other cancers.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable