The long term stability of this product in aliquots has not been determined. Various sources report that stock solutions in DMSO may be stored in aliquots at -20°C to -80°C for up to 1 year.
SML1558
Yoda1
≥98% (HPLC), powder, Piezo1 agonist
Synonym(s):
2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
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About This Item
Empirical Formula (Hill Notation):
C13H8Cl2N4S2
CAS Number:
Molecular Weight:
355.27
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
Yoda1, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
SMILES string
[s]1c(nnc1c3nccnc3)SCc2c(cccc2Cl)Cl
InChI
1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
InChI key
BQNXBSYSQXSXPT-UHFFFAOYSA-N
General description
Biochem/physiol Actions
Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland |
| form powder | form powder | form powder | form - |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 300 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 15-25°C |
| solubility DMSO: 15 mg/mL, clear | solubility DMSO: 2 mg/mL, clear (Warmed) | solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to beige | color white to beige | color white to beige | color - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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