The product is not assigned an expiration date. In the original sealed container it is quite stable. A warranty of 1 year from the date of shipment applies. It should be stored at −20°C in the powdered format. Following reconstitution in DMSO at 0.5 mg/mL, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
SML1094
CHIR 98014
≥98% (HPLC), powder, GSK-3 inhibitor
Synonym(s):
N-6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine, CHIR-98014
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About This Item
Empirical Formula (Hill Notation):
C20H17Cl2N9O2
CAS Number:
Molecular Weight:
486.31
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
CHIR 98014, ≥98% (HPLC)
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 0.5 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
NC1=C(C=CC(NCCNC2=NC(C3=C(Cl)C=C(Cl)C=C3)=C(N4C=CN=C4)C=N2)=N1)[N+]([O-])=O
InChI
1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)
InChI key
MDZCSIDIPDZWKL-UHFFFAOYSA-N
Application
CHIR 98014 has been used for the generation of small molecules neural progenitor cells and differentiation towards motor neurons.[1] It has also been used as a Wnt/β-catenin pharmacological agonist in the cell-conditioned medium to perform chromatin immunoprecipitation (ChIP) studies in HT22 neurons.[2]
Biochem/physiol Actions
CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor with IC50 values of 0.65 nM and 0.58 nM for GSK3α and GSK3β, respectively. CHIR98014 is 500-fold to >10,000-fold selectivity for GSK-3 versus 20 other protein kinases tested, including closest homologs Cdc2 and ERK2.
CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor.
Reconstitution
Reconstitute in DMSO at 0.5 mg/mL. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Storage and Stability
The product in the original sealed container is quite stable. It should be stored at −20°C in the powdered format.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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What are the storage conditions and expiry for this product in its original form and once reconstituted? Material: CHIR-98014 SML1094-25MG
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