SML0964

KNK437

≥98% (HPLC)

• Synonym(s): 3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
• Empirical Formula (Hill Notation): C₁₃H₁₁NO₄
• CAS Number: 218924-25-5
• Molecular Weight: 245.23
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O
• InChI: 1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2
• InChI key: LZGGUFLRKIMBDQ-UHFFFAOYSA-N

Description

Application

KNK437 has been used:

• as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells
• as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells
• as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release

Biochem/physiol Actions

KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.

KNK437 is a heat shock protein inhibitor.

KNK437 is a benzylidene lactam compound.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable