SML0858

SC-1

≥98% (HPLC)

• Synonym(s): N-[4-Chloro-3-(trifluoromethyl)phenyl]-N′-[4-(4-cyanophenoxy)phenyl]-urea
• Empirical Formula (Hill Notation): C₂₁H₁₃ClF₃N₃O₂
• CAS Number: 1313019-65-6
• Molecular Weight: 431.80
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

SC-1 is a derivative of the multiple tyrosine kinase inhibitor sorafenib with no kinase-inhibition activity. SC-1 blocks STAT3 phosphorylation and activation with similar potency to sorafenib, and induces apoptosis in hepatocellular carcinoma cell lines.

SC-1 is an inhibitor of STAT3 signaling pathway.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319,H413
• pcodes: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Aquatic Chronic 4 - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable