SML0285

Pleuromutilin

≥95%

• Synonym(s): Drosophilin B, Mutilin 14-glycolate, NSC 121145
• Empirical Formula (Hill Notation): C₂₂H₃₄O₅
• CAS Number: 125-65-5
• Molecular Weight: 378.50
• EC Number: 204-747-5
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825293
• NACRES: NA.77

Properties

• Assay: ≥95%
• form: powder
• optical activity: [α]/D +30 to +40° (c=1; CH2Cl2)
• color: white to beige
• solubility: DMSO: >10 mg/mL (warmed)
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]3C)OC(=O)CO
• InChI: 1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1
• InChI key: ZRZNJUXESFHSIO-BKUNHTPHSA-N

Description

Biochem/physiol Actions

Pleuromutilin is a diterpene that acts against gram positive bacteria and mycoplasm. It is present in Pleurotus mutilus and Pleurotus passecherianus. Pleuromutilin exhibits its antibacterial action by interfering with the prokaryotic 70S ribosomal subunit and inactivates initiation complex. Pleuromutilin is useful in treating mycoplasma infections in animals.

Pleuromutilin is an antibiotic natural product that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase center and inhibiting peptide bond formation.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302,H410
• Precautionary Statements: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable