Unfortunately, there is no stability information available for the product. According to the literature, this product is extremely unstable in solution and should be used shortly after reconstitution. If storage of the solution is necessary it can be held at 2-8ºC for no more than 24 hours.
SML0223
Zoledronic acid monohydrate
≥98% (HPLC), FPP synthase inhibitor, powder
Synonym(s):
P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate, Zoledronate monohydrate, [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate
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About This Item
Empirical Formula (Hill Notation):
C5H10N2O7P2·H2O
CAS Number:
Molecular Weight:
290.10
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, protect from light
Pricing and availability is not currently available.
Product Name
Zoledronic acid monohydrate, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
white to beige
solubility
H2O: ≥2 mg/mL
storage temp.
2-8°C
SMILES string
O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
InChI
1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChI key
FUXFIVRTGHOMSO-UHFFFAOYSA-N
Application
Zoledronic acid monohydrate has been used:
- as an inhibitor for cell proliferation in glioblastoma, breast cancer tumor and prostate cancer cell line LAPC4
- as a conjugate with
D ,L -lactide 75: glycolide 25 (PLGA) to analyze its bone formation functionality in distal femur - as an inhibitor for farnesyl diphosphate synthase enzyme in glioblastoma cells
Biochem/physiol Actions
Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.
Zoledronic acid (zoledronate) is a bone resorption inhibitor, an inhibitor of farnesyl diphosphate synthase
Preparation Note
This product is extremely unstable in solution and should be used shortly after reconstitution. If storage of the solution is necessary it can be held at 2-8ºC for no more than 24 hours.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description European Pharmacopoeia (EP) Reference Standard | description United States Pharmacopeia (USP) Reference Standard | description Pharmaceutical Secondary Standard; Certified Reference Material |
| form powder | form - | form - | form powder |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 300 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-30°C |
| solubility H2O: ≥2 mg/mL | solubility - | solubility - | solubility - |
| storage condition protect from light, desiccated | storage condition - | storage condition - | storage condition - |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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After dissolving in H2O, how should the solution be stored and what is the shelf life after dilution?
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