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Key Documents

SAB2501686

Sigma-Aldrich

Anti-NOX1 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

GP91-2, MOX1, NADPH oxidase 1, NOH-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, bovine, canine

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NOX1(27035)

General description

NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.

Immunogen

Peptide with sequence C-DKATDIVTGLKQK, from the internal region of the protein sequence according toNP_008983.2; NP_39249.1

Application

Anti-NOX1 antibody produced in goat has been used for Western blotting.

Biochem/physiol Actions

NOX1 catalyzes the production of hydrogen peroxide (H2O2). Overexpression of the protein leads to the production of superoxide and H2O2 and triggers angiogenic switch, mediating vascularization and rapid expansion of the tumor. Elevated expression of NOX1 has been observed in the brain of Parkinson′s disease (PD) patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning
Shuxia Jiang
Cardiovascular Research, 102(1) (2014)
NADPH oxidases in Parkinson?s disease: a systematic review
Karim Belarbi
Molecular Neurobiology, 12(84) (2017)
LRRC8A channels support TNFa-induced superoxide production by Nox1 which is required for receptor endocytosis
Hyehun Choi
Free Radical Biology & Medicine, 413-423 (2016)
Reactive oxygen generated by Nox1 triggers the angiogenic switch
Jack L
Proceedings of the National Academy of Sciences of the USA, 99(2), 715-720 (2000)
Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
Lula L
Arteriosclerosis, Thrombosis, and Vascular Biology, 24(4) (2004)

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