Key Documents

Anti-Caspase-1 (ab2) antibody produced in rabbit

Name: Anti-Caspase-1 (ab2) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Caspase 1, apoptosis-related cysteine peptidase (Interleukin 1, beta, convertase), Anti-ICE, Anti-IL-1β converting enzyme

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Technique(s):

western blot: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable

Conjugate:

unconjugated

Application:

ELISA (i), IF, IHC, WB

Citations:

Pricing and availability is not currently available.

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable

UniProt accession no.

P29466

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CASP1(834)

Description

General description

Caspase-1 is also known as interleukin-1βconverting enzyme (ICE). It is located on chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. It is present in leukocytes, monocytes and epithelial cells.

Immunogen

a 15 amino acid peptide from near the middle of human Caspase-1.

Biochem/physiol Actions

Caspase-1 can transform the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients.It helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3463.

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This Item	WH0000834M1	SAB5700660	SAB4503271
Sigma-Aldrich PRS3463 Anti-Caspase-1 (ab2) antibody produced in rabbit	Sigma-Aldrich WH0000834M1 Monoclonal Anti-CASP1 antibody produced in mouse	Sigma-Aldrich SAB5700660 Anti-Caspase 1 antibody produced in rabbit	Sigma-Aldrich SAB4503271 Anti-CASP1, C-Terminal antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description clone 3D2, purified immunoglobulin, buffered aqueous solution	description -	description affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
shipped in dry ice	shipped in dry ice	shipped in wet ice	shipped in wet ice
technique(s) immunofluorescence: suitable, indirect ELISA: suitable, western blot: suitable, immunohistochemistry: suitable	technique(s) indirect ELISA: suitable, western blot: 1-5 μg/mL, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable	technique(s) immunofluorescence: 1:50-1:200, western blot: 1:500-1:2000, immunohistochemistry: 1:50-1:200, immunoprecipitation (IP): 1:50-1:100	technique(s) immunohistochemistry: 1:50-1:100, ELISA: 1:20000, western blot: 1:500-1:1000

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Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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