This product is not tested for suitability in HPLC. Unfortunately, no other Dihydrochloride form is tested for HPLC applications. However, the base form, available as a standard under product number 51799, has been tested for suitability in HPLC and GC. In addition, the purity of product D13208, 1,4-Diaminobutane (Putrescine), is determined by GC. Please see the links below to review these product options.
51799, Putrescine, analytical standard
https://www.sigmaaldrich.com/US/en/product/sial/51799
D13208, 1,4-Diaminobutane, 99%
https://www.sigmaaldrich.com/US/en/product/aldrich/d13208
P7505
Putrescine dihydrochloride
≥98% (TLC), powder
Synonym(s):
1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride
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About This Item
Linear Formula:
NH2(CH2)4NH2 · 2HCl
CAS Number:
Molecular Weight:
161.07
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-375-9
MDL number:
Beilstein/REAXYS Number:
3906680
Assay:
≥98% (TLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
Putrescine dihydrochloride, ≥98% (TLC)
Quality Segment
assay
≥98% (TLC)
form
powder
mp
280 °C (dec.) (lit.)
solubility
H2O: soluble 100 mg/mL, clear, colorless
SMILES string
Cl[H].Cl[H].NCCCCN
InChI
1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
InChI key
XXWCODXIQWIHQN-UHFFFAOYSA-N
Application
Putrescine dihydrochloride has been used:
- as a bioactive amine standard in high-performance liquid chromatography (HPLC)
- as a component of hormone mix supplemented to Dulbecco′s modified eagle medium (DMEM) to study its effects on neural stem cells
- as a supplement in DMEM for culturing of endometrial cancer cells
Biochem/physiol Actions
Putrescine is an aliphatic amine and is positively charged. It acts as a precursor of spermine and plays a role in polyamine biosynthesis. Putrescine is found in several plants, animals, and bacteria. It plays a role in cell proliferation and cell growth in Escherichia coli. Putrescine is a component of agrochemicals, surfactants, pharmaceuticals, polymers, and additives.
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.
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This Item | |||
|---|---|---|---|
| description ≥98% (TLC) | description powder, BioReagent, suitable for cell culture | description purum, ≥99.0% (AT) | description γ-irradiated, lyophilized powder, BioXtra, suitable for cell culture |
| assay ≥98% (TLC) | assay ≥97% (TLC) | assay ≥99.0% (AT) | assay ≥97% (HPLC) |
| form powder | form powder | form powder | form lyophilized powder |
| Quality Level 400 | Quality Level 200 | Quality Level 400 | Quality Level 200 |
| solubility H2O: soluble 100 mg/mL, clear, colorless | solubility H2O: 100 mg/mL | solubility water: soluble 1 g/10 mL, clear, colorless | solubility cell culture medium: 0.16 mg/mL |
| mp 280 °C (dec.) (lit.) | mp 280 °C (dec.) (lit.) | mp 280 °C (dec.) (lit.) | mp 280 °C (dec.) (lit.) |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 1
Flash Point (°F)
113.0 °F - closed cup
Flash Point (°C)
45 °C - closed cup
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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if Putrescine dihydrochloride (P7505, ≥98% TLC) is suitable for HPLC analysis? If not, please recommend an alternative HPLC-grade putrescine product
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