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PD 98,059

Name: PD 98,059
Brand: SIGMA

MAPKK inhibitor, solid

Synonym(s):

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₃NO₃

CAS Number:

167869-21-8

Molecular Weight:

267.28

UNSPSC Code:

12352200

PubChem Substance ID:

24278666

NACRES:

NA.77

MDL number:

MFCD00671789

Form:

solid

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Properties

Product Name

PD 98,059, solid

form

solid

Quality Segment

100

color

yellow

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

Gene Information

human ... MAP2K1(5604), MAP2K2(5605), MAP2K3(5606), MAP2K4(6416), MAP2K5(5607), MAP2K6(5608), MAP2K7(5609), MAP3K1(4214), RAF1(5894)

Description

Application

PD 98,059 has been used:

in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
in culture medium for cell migration assay

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with permission of Warner Lambert Company.

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This Item	513001	L9908	SML0551
Sigma-Aldrich P215 PD 98,059	Sigma-Aldrich 513001 PD 98059	Sigma-Aldrich L9908 LY-294,002 hydrochloride	Sigma-Aldrich SML0551 Icaritin
description solid	description InSolution, ≥98%, 5 mg/ml, reversible inhibitor of MAP Kinase Kinase (MEK)	description solid, ≥98% (HPLC)	description ≥98% (HPLC)
form solid	form liquid	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL, clear	solubility -	solubility H₂O: insoluble, DMSO: >5 mg/mL	solubility DMSO: 5 mg/mL, clear (warmed)
color yellow	color -	color white to off-white	color light yellow to dark yellow
Gene Information human ... MAP2K1(5604), MAP2K2(5605), MAP2K3(5606), MAP2K4(6416), MAP2K5(5607), MAP2K6(5608), MAP2K7(5609), MAP3K1(4214), RAF1(5894)	Gene Information -	Gene Information -	Gene Information -

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Storage Class

11 - Combustible Solids

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