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N7251

Sigma-Aldrich

4-Nitrocatechol sulfate dipotassium salt

crystalline

Synonym(s):

2-Hydroxy-5-nitrophenyl sulfate, 2-Hydroxy-5-nitrophenyl sulfate dipotassium salt monohydrate, p-Nitrocatechol sulfate dipotassium salt

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About This Item

Linear Formula:
C6H3NO7SK2
CAS Number:
14528-64-4
Molecular Weight:
311.35
Beilstein:
3805018
EC Number:
238-550-0
MDL number:
MFCD00007465
UNSPSC Code:
12352200
PubChem Substance ID:
24897816
NACRES:
NA.77

form

crystalline

color

yellow

storage temp.

−20°C

SMILES string

[K+].[K+].[O-]c1ccc(cc1OS([O-])(=O)=O)[N+]([O-])=O

InChI

1S/C6H5NO7S.2K/c8-5-2-1-4(7(9)10)3-6(5)14-15(11,12)13;;/h1-3,8H,(H,11,12,13);;/q;2*+1/p-2

InChI key

CKWWBDCAYRJAJB-UHFFFAOYSA-L

General description

4-Nitrocatechol sulfate is an aromatic sulfate.

Application

4-Nitrocatechol sulfate dipotassium salt has been used as a substrate in mucopolysaccharidoses VI (MPS VI) analysis. It has also been used to measure the activity of glycosaminoglycan (GAG)-degrading enzymes-arylsulfatase B, and exoglycosidases.

Substrates

Chromogenic sulfatase substrate.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jin-Peng Sun et al.
The Journal of biological chemistry, 278(35), 33392-33399 (2003-06-18)
The pathogenic bacteria Yersinia are causative agents in human diseases ranging from gastrointestinal syndromes to bubonic plague. There is increasing risk of misuse of infectious agents, such as Yersinia pestis, as weapons of terror as well as instruments of warfare
The convulsive effects of dopamine sulfate conjugates in rat brain.
N T Buu et al.
Life sciences, 29(22), 2311-2316 (1981-11-30)
Ilhem Barboura et al.
Diagnostic pathology, 7, 11-11 (2012-01-31)
Metachromatic leukodystrophy (MLD) is a recessive autosomal disease which is characterized by an accumulation of sulfatides in the central and peripheral nervous system. It is due to the enzyme deficiency of the sulfatide sulfatase i.e. arylsulfatase A (ASA). we studied
D B Thompson et al.
Experientia, 42(2), 150-151 (1986-02-15)
Rodent and bovine arylsulfatase B hydrolyze 4-methylumbelliferyl sulfate (4MUS) 10- to 30-fold more efficiently than arylsulfatase A. Therefore, 4MUS grossly underestimates arylsulfatase A activity in the presence of excess arylsulfatase B.
P L Chang et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 32(6), 617-624 (1984-06-01)
A staining reaction was developed to specifically detect arylsulfatase A activity in the presence of arylsulfatases B and C. Nitrocatechol, generated by all arylsulfatases from the substrate p-nitrocatechol sulfate, can be coupled to produce Hatchett 's brown which reacts with
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