M6824
gamma-Mangostin
≥98% (HPLC)
Synonym(s):
1,3,6,7-Tetrahydroxy-2,8-bis(3,3-dimethylallyl)xanthone, Demethylmangostin, Normangostin
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About This Item
Empirical Formula (Hill Notation):
C23H24O6
CAS Number:
Molecular Weight:
396.43
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
off-white to yellow
solubility
methanol: 1 mg/mL, colorless to yellow
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
OC1=CC(OC2=CC(O)=C(CC=C(C)C)C(O)=C2C3=O)=C3C(CC=C(C)C)=C1O
InChI
1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3
InChI key
VEZXFTKZUMARDU-UHFFFAOYSA-N
General description
The fruit hulls of mangosteen contain three major bioactive compounds namely, α-, β-, and γ-mangostin.
Application
γ-Mangostin has been used to study its inhibitory effect on Transthyretin (TTR) fibrillization, a homotetrameric protein involved in human hereditary amyloidosis.
Biochem/physiol Actions
The xanthone derivatives, namely α-, β-, and γ-mangostin have various biological activities including antiproliferative and anti-inflammatory activity, enhancement of natural killer (NK) cell activity, and antiviral effect against human immunodeficiency virus (HIV). γ-Mangostin is also reported to inhibit cyclooxygenase (COX-2) activity and NO production, which in turn reduces the level of prostaglandin E2. It is found to induce cell death in human colon cancer cells.
Xanthone derivative isolated from the mangosteen hull (Garcinia mangostana). Exhibits antioxidant and anticancer properties. Mangosteen xanthones inhibit inflammation in human adipocytes which is important in understanding obesity-associated inflammation and the development of insulin resistance.
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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K Furukawa et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 110 Suppl 1, 153P-158P (1998-03-21)
A crude methanolic extract of the fruit hull of Garcinia mangostana L. inhibited the contraction of the isolated rabbit aorta induced by histamine and serotonin. The extract has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give
N Chairungsrilerd et al.
Planta medica, 62(5), 471-472 (1996-10-01)
A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring
Lih-Geeng Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(2), 688-693 (2007-11-22)
The fruit hull of Garcinia mangostana Linn (Guttiferae) is used as an anti-inflammatory drug in Southeast Asia. Two xanthones, alpha- and gamma-mangostins, were isolated from the fruit hull of G. mangostana, and both significantly inhibited nitric oxide (NO) and PGE(2)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M6824-50MG | 04061833050729 |
| M6824-10MG | 04061833050712 |