M6045

2-Methyl-4-isothiazolin-3-one hydrochloride

≥99%

• Synonym(s): MIT hydrochloride, Methylisothiazolinone hydrochloride
• Empirical Formula (Hill Notation): C₄H₅NOS · HCl
• CAS Number: 26172-54-3
• Molecular Weight: 151.61
• UNSPSC Code: 51102829
• NACRES: NA.76
• PubChem Substance ID: 24897073
• EC Number: 247-499-3
• Beilstein/REAXYS Number: 3993054
• MDL number: MFCD06804636

Properties

• Quality Segment: 200
• biological source: synthetic
• assay: ≥99%
• form: powder
• concentration: ≤ 100%
• technique(s): cell culture | mammalian: suitable
• color: white to beige
• mp: 165—170 °C ((329 - 338 °F) at ca.990.4 hPa)
• solubility: water: soluble 10.0 — 10.4 mg/mL, clear, colorless to faint yellow or tan
• suitability: suitable for component for culture media
• application(s): microbiology
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN1SC=CC1=O
• InChI: 1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
• InChI key: SJXPQSRCFCPWQQ-UHFFFAOYSA-N

Description

General description

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a derivative of the synthetic isothiazolinone.

Application

Methylisothiazolinone (MIT HCl) has been used:

• as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
• to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a skin sensitizerPMID 33290830 known to cause contact dermatitis and allergy.PMID 21777214 It is extensively used in the cosmetic industry as a preservative.PMID 23340392 MIT HCl is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.PMID 16547166PMID 12196562

Safety Information

• pictograms: GHS06,GHS05,GHS09
• signalword: Danger
• hcodes: H301,H314,H317,H410
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1
• supp_hazards: EUH071
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges