M4949

2′-C-Methylcytidine

≥95% (HPLC), powder

• Synonym(s): 2′-C-Methyl Cytidine, NM107
• Empirical Formula (Hill Notation): C₁₀H₁₅N₃O₅
• CAS Number: 20724-73-6
• Molecular Weight: 257.24
• NACRES: NA.77
• PubChem Substance ID: 329817997
• UNSPSC Code: 12352200
• MDL number: MFCD02682947
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: H₂O: >20 mg/mL
• storage temp.: −20°C
• SMILES string: C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N2C=CC(N)=NC2=O
• InChI: 1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1
• InChI key: PPUDLEUZKVJXSZ-VPCXQMTMSA-N

Description

Biochem/physiol Actions

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable