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Indomethacin

Name: Indomethacin
Brand: SIGMA

meets USP testing specifications

Synonym(s):

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₆ClNO₄

CAS Number:

53-86-1

Molecular Weight:

357.79

UNSPSC Code:

12352101

NACRES:

NA.21

PubChem Substance ID:

24896136

EC Number:

200-186-5

Beilstein/REAXYS Number:

497341

MDL number:

MFCD00057095

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Properties

Quality Segment

200

agency

USP/NF, meets USP testing specifications

assay

98.0-102.0%

form

powder

mode of action

enzyme | inhibits

SMILES string

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChI key

CGIGDMFJXJATDK-UHFFFAOYSA-N

Gene Information

human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224), Ptgs2(19225)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

Description

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.

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This Item	I7378	405268	111902
Sigma-Aldrich I8280 Indomethacin	Sigma-Aldrich I7378 Indomethacin	Sigma-Aldrich 405268 Indomethacin	Sigma-Aldrich 111902 4-Chlorobenzoyl chloride
mode of action enzyme \| inhibits	mode of action enzyme \| inhibits	mode of action -	mode of action -
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
assay 98.0-102.0%	assay 98.0-102.0% (in accordance with EP)	assay ≥98% (by assay)	assay 99%
form powder	form powder or crystals	form powder	form -
Gene Information human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743) mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224), Ptgs2(19225) rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)	Gene Information human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743) mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224) rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)	Gene Information -	Gene Information -
agency USP/NF, meets USP testing specifications	agency meets EP testing specifications	agency -	agency -

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pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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