F8055

FGR, active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(s): SRC2, c-fgr, p55c-fgr
• NACRES: NA.32
• UNSPSC Code: 51111800

Properties

• recombinant: expressed in baculovirus infected Sf9 cells
• Quality Segment: 200
• product line: PRECISIO^® Kinase
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 242-328 nmol/min·mg
• mol wt: ~86 kDa
• UniProt accession no.: P09769
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FGR(2268)

Description

General description

Src family of tyrosine kinases is grouped into two classes- those with wide range of expression, and those with narrow range of tissue expression. Fgr belongs to the latter group. This protein has six functional domains namely, Src homology domain 4 (SH4), a unique domain, SH3 domain, SH2 domain, the catalytic SH1 domain, and a regulatory region in C-terminal. It is expressed in natural killer cells, monocytes and granulocytes.

Biochem/physiol Actions

FGR interacts with Fc?RII and thus, regulates Fc?RII-mediated signaling cascade.
This protein is expressed in B-cells of patients with Epstein-Barr virus-associated lymphoproliferative disease and chronic lymphocytic leukemia. It is also expressed in normal mantle zone B-cells and is controlled developmentally during the differentiation of myelomonocytes.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)