D9160

1-Deoxymannojirimycin hydrochloride

• Synonym(s): 1-Deoxymannojirimycin HCl, 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₃NO₄ · HCl
• CAS Number: 73465-43-7
• Molecular Weight: 199.63
• NACRES: NA.76
• PubChem Substance ID: 24894265
• UNSPSC Code: 51102829
• MDL number: MFCD00083611

Properties

• form: powder
• Quality Segment: 200
• color: white to off-white
• solubility: H₂O: 10 mg/mL
• antibiotic activity spectrum: viruses
• mode of action: enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1
• InChI key: ZJIHMALTJRDNQI-MVNLRXSJSA-N

Description

General description

Chemical structure: glucosamine

Application

1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.

Biochem/physiol Actions

1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.

Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves