C6303

Calphostin C

From microbial (Cladosporium cladosporioides), ≥90% (HPLC), protein kinase C inhibitor, powder

• Synonym(s): UCN-1028c
• Empirical Formula (Hill Notation): C₄₄H₃₈O₁₄
• CAS Number: 121263-19-2
• Molecular Weight: 790.76
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892857
• NACRES: NA.77
• MDL number: MFCD00133155

Properties

• Product Name: Calphostin C from Cladosporium cladosporioides, ≥90% (HPLC), powder
• biological source: microbial (Cladosporium cladosporioides)
• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: powder
• color: red to brown
• solubility: DMF: 1 mg/mL, DMSO: 1 mg/mL, ethanol: 1 mg/mL
• storage temp.: −20°C
• SMILES string: COc1cc(O)c2C(=O)C(OC)=C(CC(C)OC(=O)Oc3ccc(O)cc3)c4c5C(CC(C)OC(=O)c6ccccc6)=C(OC)C(=O)c7c(O)cc(OC)c(c57)c1c24
• InChI: 1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3
• InChI key: SRJYZPCBWDVSGO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Highly specific inhibitor of protein kinase C (IC₅₀ = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

Features and Benefits

This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)