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C6240

CITCO

≥98% (HPLC), androstane receptor agonist, solid

Synonym(s):

6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime

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About This Item

Empirical Formula (Hill Notation):
C19H12N3OCl3S
CAS Number:
338404-52-7
Molecular Weight:
436.74
UNSPSC Code:
12352203
PubChem Substance ID:
24724448
NACRES:
NA.77
MDL number:
MFCD00139608
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200
Storage condition:
desiccated
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Product Name

CITCO, ≥98% (HPLC), solid

Quality Level

200

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: soluble 28 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4

InChI

1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+

InChI key

ZQWBOKJVVYNKTL-AUEPDCJTSA-N

General description

CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.

Application

CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.

Biochem/physiol Actions

CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.

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This Item
385920565840SML2410
CITCO ≥98% (HPLC), solid

Sigma-Aldrich

C6240

CITCO

HSP90 Inhibitor, CCT018159 The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.

Sigma-Aldrich

385920

HSP90 Inhibitor, CCT018159

SHIP2 Inhibitor, AS1938909 The SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

565840

SHIP2 Inhibitor, AS1938909

ABC99 ≥98% (HPLC)

Sigma-Aldrich

SML2410

ABC99

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

powder

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

desiccated

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

-

solubility

DMSO: soluble 28 mg/mL, H2O: insoluble

solubility

water: 1.7 mg/mL, DMSO: 35 mg/mL, ethanol: 35 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 2 mg/mL, clear

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000546836
0000546836
0000505990
0000505990
0000235541

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
Maglich JM, et al.
The Journal of Biological Chemistry, 278(19), 17277-17283 (2003)
Tadeja Režen et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 974-976 (2017-05-26)
Statins are well known lipid lowering agents that inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. They also activate drug metabolism but their exact receptor-mediated action has not been proven so far. We tested whether atorvastatin and rosuvastatin are direct ligands of
Cristina Saez-Lopez et al.
Scientific reports, 7(1), 12284-12284 (2017-09-28)
Sex hormone-binding globulin (SHBG) carries sex steroids in blood regulating their bioavailability. Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red wine, acts specifically through the human constitutive androstane receptor (CAR)
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Global Trade Item Number

SKUGTIN
C6240-5MG04061833511008

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