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Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

Name: Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
Brand: SIGMA

Cathepsin B substrate, powder

Synonym(s):

Z-RR-AMC

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₃₉N₉O₆

CAS Number:

136132-67-7

Molecular Weight:

621.69

UNSPSC Code:

12352209

PubChem Substance ID:

24892784

NACRES:

NA.32

MDL number:

MFCD00133576

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Properties

Product Name

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,

form

powder

Quality Segment

200

impurities

~4% isopropanol

storage temp.

−20°C

SMILES string

Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12

InChI

1S/C30H39N9O6.ClH/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-26(41)22(9-5-13-35-28(31)32)38-27(42)23(10-6-14-36-29(33)34)39-30(43)44-17-19-7-3-2-4-8-19;/h2-4,7-8,11-12,15-16,22-23H,5-6,9-10,13-14,17H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,31,32,35)(H4,33,34,36);1H

InChI key

HLSNWWKWVKPXKI-UHFFFAOYSA-N

Gene Information

human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)

Description

General description

Fluorogenic substrate for cathepsin B.

Application

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

as a cathepsin B substrate in zymography analysis of protease in feces extract.
in cathepsin B activity assay.
as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

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This Item	M0938	219392	EMU034841
Sigma-Aldrich C5429 Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	Sigma-Aldrich M0938 7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide	Sigma-Aldrich 219392 Cathepsin B Substrate III, Fluorogenic	Sigma-Aldrich EMU034841 MISSION^® esiRNA
description -	description >97% (HPLC), solid	description Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.	description targeting mouse Ctsb
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
form powder	form solid	form lyophilized solid	form lyophilized powder
Gene Information human ... CTSB(1508) mouse ... CTSB(13030) rat ... CTSB(64529)	Gene Information human ... CTSD(1509), CTSE(1510) mouse ... CTSD(13033), CTSE(13034) rat ... CTSD(171293), CTSE(25424)	Gene Information -	Gene Information mouse ... CTSB(13030), Ctsb(13030)
impurities ~4% isopropanol	impurities -	impurities -	impurities -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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