A9561

5-(N,N-Hexamethylene)amiloride

• Synonym(s): HMA
• Empirical Formula (Hill Notation): C₁₂H₁₈ClN₇O
• CAS Number: 1428-95-1
• Molecular Weight: 311.77
• NACRES: NA.77
• PubChem Substance ID: 24278246
• UNSPSC Code: 12352200
• MDL number: MFCD00069211
• Form: powder

Properties

• form: powder
• Quality Segment: 200
• storage temp.: 2-8°C
• SMILES string: N\C(N)=N\C(=O)c1nc(Cl)c(nc1N)N2CCCCCC2
• InChI: 1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)
• InChI key: RQQJJXVETXFINY-UHFFFAOYSA-N
• Gene Information: human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553) ; mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) ; rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a3(24784)

Description

Biochem/physiol Actions

Inhibitor of Na⁺/H⁺ antiport.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301 + H311 + H331
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges