94740

Vanadyl ribonucleoside complexes

powder

• Synonym(s): Ribonucleoside vanadyl complexes, VRC
• UNSPSC Code: 12352200
• NACRES: NA.52
• Form: powder
• Storage temp.: −20°C

Properties

• Product Name: Vanadyl ribonucleoside complexes, BioReagent, Molecular Biology
• grade: Molecular Biology
• Quality Segment: 100
• product line: BioReagent
• form: powder
• suitability: in accordance for ribonuclease inhibition test
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

Vanadyl ribonucleoside complexes are low molecular weight inhibitors of ribonucleases.

Application

Vanadyl ribonucleoside complexes has been used in hybridization mixture for RNA in situ hybridization.

Vanadyl ribonucleoside complexes (VDR) are transition state analogs that bind to active sites of many RNases, inhibiting their activity. Because the RNases are not covalently modified by the complexes, VDR must be used at every stage of RNA extraction and purification. However, VDR also inhibit RNA polymerases and in vitro translation and therefore must be removed from final preparation of RNA.

Biochem/physiol Actions

The vanadyl ribonucleoside complex has the ability to block the formation of ribosomal subunit in Staphylococcus aureus. The complex exhibits anti-microbial activity These complexes also serve as powerful inhibitors of several enzymes with ribonucleolytic activity.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)