To neutralize 0.5 L of 120 mM 66930 solution, it is recommended to use 8 ml of 0.5 N HCl to adjust the pH to 8, and then dilute the HCl (e.g. 0.1 N) to titrate to pH 7.3. This approach can help avoid the drastic drop in pH.
66930
N-Methyl-D-glucamine
ReagentPlus®, ≥99.0% (T)
Synonym(s):
1-Deoxy-1-(methylamino)-D-glucitol, Meglumine
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About This Item
Empirical Formula (Hill Notation):
C7H17NO5
CAS Number:
Molecular Weight:
195.21
UNSPSC Code:
12352104
NACRES:
NA.22
PubChem Substance ID:
EC Number:
228-506-9
Beilstein/REAXYS Number:
385906
MDL number:
Pricing and availability is not currently available.
biological source
synthetic
Quality Segment
product line
ReagentPlus®
assay
≥99.0% (T)
form
powder
optical activity
[α]20/D −16.5±0.5°, c = 2% in H2O
autoignition temp.
~662 °F
mp
126-131 °C, 129-131.5 °C (lit.)
solubility
H2O: 0.1 g/mL, clear, colorless
anion traces
chloride (Cl-): ≤50 mg/kg, phosphate (PO43-): ≤5 mg/kg, sulfate (SO42-): ≤50 mg/kg
cation traces
Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤20 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg
SMILES string
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI
1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1
InChI key
MBBZMMPHUWSWHV-BDVNFPICSA-N
General description
N-Methyl-D-glucamine, also known as Meglumine, is a sorbitol-derived amino sugar. It acts as a catalyst in one-pot synthesis of pyranopyrazole derivatives.
Application
N-Methyl-D-glucamine is utilized as:
- An ion exchange resin due to its high affinity and selectivity for specific ions
- A buffering agent to remove boron from an aqueous solution
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
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This Item | |||
|---|---|---|---|
| description ReagentPlus®, ≥99.0% (T) | description 99.0-100.5% (titration) | description United States Pharmacopeia (USP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard |
| biological source synthetic | biological source - | biological source - | biological source - |
| assay ≥99.0% (T) | assay 99.0-100.5% (titration) | assay - | assay - |
| solubility H2O: 0.1 g/mL, clear, colorless | solubility - | solubility - | solubility - |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level - |
| form powder | form powder | form - | form - |
| mp 129-131.5 °C (lit.), 126-131 °C | mp 129-131.5 °C (lit.) | mp 129-131.5 °C (lit.) | mp 129-131.5 °C (lit.) |
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Storage Class
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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What is the optimal volume of HCl to use in order to achieve a pH of 7.3 when using N-Methyl-D-glucamine (P/N: 66930) in a patch clamp solution without adding any additional Na+ ions?
1 answer-
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When preparing a solution for patch clamping, what is the best optimal amount of HCL to use for ensuring that NaOH will not be required to maintain pH 7.3? F
1 answer-
The necessary amount of HCl would need to be determined by the end-user. It is recommended to record the initial pH value prior to the addition of HCl. After recording the intial pH, add small increments of HCl (1-2 mL). The molarity of the HCL must also be considered when adding incremental volumes. A 1M HCl would be considered fairly dilute. Higher concentrations would require volume adjustments. Record the pH value after 5 minutes of stirring.
For further questions or concerns, please navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.
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