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61347

Supelco

10,11-Dihydro-10-hydroxycarbamazepine

analytical standard

Synonym(s):

10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, Licarbazepine

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About This Item

Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
29331-92-8
Molecular Weight:
254.28
Beilstein:
1540211
MDL number:
MFCD00871817
UNSPSC Code:
41116107
PubChem Substance ID:
329759441
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥99% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)

InChI key

BMPDWHIDQYTSHX-UHFFFAOYSA-N

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General description

10,11-Dihydro-10-hydroxycarbamazepine is a 10-hydroxy derivative and an active metabolite of oxcarbazepine.
10,11-Dihydro-10-hydroxycarbamazepine is an active metabolite of the antiepileptic drug, oxcarbazepine.

Application

10,11-Dihydro-10-hydroxycarbamazepine may be used as a reference standard in the determination of 10,11-dihydro-10-hydroxycarbamazepine in biological samples using liquid chromatography, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Environment
GHS09

Hazard Statements

H411

Precautionary Statements

P273

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK4194
BCCC9313
BCBT7305
BCBM2422V
BCBM2422

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Juhyun Sim et al.
Forensic science international, 274, 91-98 (2017-01-24)
In recent years, the inappropriate use of antipsychotics by young Korean men has become a social problem. As military service exemptions are given for mental illness, some men pose as mental health patients to avoid military service. In order to
Liquid chromatographic analysis of oxcarbazepine and its metabolites in plasma and saliva after a novel microextraction by packed sorbent procedure.
Saracino M A, et al.
Analytica Chimica Acta, 661(2), 222-228 (2010)
Binding of licarbazepine enantiomers to mouse and human plasma proteins.
Fortuna A, et al.
Biopharmaceutics & Drug Disposition, 31(5-6), 362-366 (2010)
Simultaneous quantitative analysis of oxcarbazepine and 10, 11-dihydro-10-hydroxycarbamazepine in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Maia SdBM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(2), 304-311 (2007)
Depression and Bipolar Disorder: Stahl's Essential Psychopharmacology, 3rd Edition (2008)
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