ABS1673
Anti-Uteroglobin
serum, from goat
Synonym(s):
Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, PCB-binding protein, Secretoglobin family 1A member 1, Blastokinin
Sign Into View Organizational & Contract Pricing
All Photos(3)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.43
Recommended Products
biological source
goat
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
species reactivity (predicted by homology)
rat (based on 100% sequence homology)
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Gene Information
mouse ... Scgb1A1(22287)
rat ... Scgb1A1(25575)
General description
Uteroglobin (UniProt: P17559; also known as Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, PCB-binding protein, Secretoglobin family 1A member 1, Blastokinin) is encoded by the Scgb1a1 (also known as Cc10, Ugb, Utg) gene (Gene ID: 25575) in rat. Uteroglobin, is a member of the Secretoglobin superfamily that serves as a multifunctional protein and can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules. Uteroglobin is synthesized with a signal peptide of 19 amino acids and consists of a disulfide-linked dimer of two identical polypeptides, each polypeptide being composed of four helices. Uteroglobin derives its name from its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects. It is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways. It plays a role in sequestering pro-inflammatory mediators and carcinogens and has been implicated in the inhibition of cell migration and invasion. It inhibits soluble phospholipase A2 activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, phospholipids, prostaglandins, and retinols. Uteroglobin positive (Scgb1a1+) cells in different regions of the lung differ in their role as progenitors in vivo. For example, in the bronchioles, these cells can both self-renew and generate ciliated cells during postnatal growth and adult homeostasis. On the other hand, in the trachea, the majority of uteroglobin positive cells constitute a transient amplifying population during postnatal growth and steady state, and their capacity for self-renewal and multi-lineage differentiation increases in response to injury. (Ref.: Mukherjee, AB et al. (2007). Endocrine Rev. 28(7): 707-725).
Specificity
This polyclonal antibody detects uteroglobin in mouse and rat tissues.
Immunogen
Epitope: unknown
His-tagged full length recombinant rat uteroglobin.
Application
Detect Uteroglobin using this goat polyclonal Anti-Uteroglobin Antibody, Cat. No. ABS1673 that has been tested in Immunofluorescence, immunohistochemistry, and Western blotting.
Immunofluorescence Analysis: A representative lot detected Uteroglobin in dedifferentiated cells (Tata, P.R., et. al. (2013). Nature. 503(7475):218-23) and mice E18.5 lung tissue (Hashimoto, S., et. al. (2012). J Cell Sci. 125(Pt 4):932-42).
Immunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected Uteroglobin in mouse lung tissue. (Courtesy of Dr.Barry Stripp at Cedars-Sinai Medical Center, Los Angeles, CA).
Immunohistochemistry Analysis: A representative lot detected Uteroglobin in adult mice alveoli (Rawlins, E.L., et. al. (2009). Cell Stem Cell. 4(6):525-34).
Immunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected Uteroglobin in mouse lung tissue. (Courtesy of Dr.Barry Stripp at Cedars-Sinai Medical Center, Los Angeles, CA).
Immunohistochemistry Analysis: A representative lot detected Uteroglobin in adult mice alveoli (Rawlins, E.L., et. al. (2009). Cell Stem Cell. 4(6):525-34).
Research Category
Signaling
Signaling
Quality
Evaluated by Western Blotting in mouse lung tissue lysate.
Western Blotting Analysis: A 1:500 dilution of this antibody detected Uteroglobin in 10 µg of mouse lung tissue lysate.
Western Blotting Analysis: A 1:500 dilution of this antibody detected Uteroglobin in 10 µg of mouse lung tissue lysate.
Target description
~10 kDa observed; 10.45 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physical form
Goat polyclonal antiserum with 0.05% sodium azide.
Unpurified
Storage and Stability
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Evgenia Dobrinskikh et al.
American journal of physiology. Lung cellular and molecular physiology, 321(5), L941-L953 (2021-09-30)
Both preclinical and clinical studies have demonstrated that exposures to acetaminophen (APAP) at levels that cause hepatic injury cause pulmonary injury as well. However, whether exposures that do not result in hepatic injury have acute pulmonary implications is unknown. Thus
Sung-Hee Kim et al.
Frontiers in immunology, 13, 1055811-1055811 (2022-12-03)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike protein infects the host by binding to angiotensin-converting enzyme 2 (ACE2) expressed on the cell surface, which
Simon J Cleary et al.
The Journal of clinical investigation, 134(11) (2024-03-26)
Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, in reactions to transfusions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. Harmful antibodies often activate the
Vitaly Ievlev et al.
Frontiers in medicine, 10, 1144754-1144754 (2023-04-28)
The field of airway biology research relies primarily on in vitro and in vivo models of disease and injury. The use of ex vivo models to study airway injury and cell-based therapies remains largely unexplored although such models have the
Sarah R Leist et al.
Cell, 183(4), 1070-1085 (2020-10-09)
The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard laboratory mice. This SARS-CoV-2 model exhibits the spectrum of morbidity
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service