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Key Documents

AB1570W

Sigma-Aldrich

Anti-GABA Transporter-1 Antibody

Chemicon®, from rabbit

Synonym(s):

GAT-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rabbit, mouse, monkey, human, rat, feline

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_003042.2

UniProt accession no.

P30531

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SLC6A1(6529)

Specificity

Recognizes GABA Transporter-1 (GAT-1), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.

Immunogen

Rat GAT-1, C-terminus (aa 588-599)

Application

Anti-GABA Transporter-1 Antibody detects level of GABA Transporter-1 & has been published & validated for use in IH & WB.
Western blotting: 1:200-1:500 (67 kDa)

Immunohistochemistry

Optimal working dilutions must be determined by the end user.

Target description

67 kDa

Physical form

Affinity Purified antibody. Lyophilized from 0.1 M PBS with 1% BSA and 0.1% sodium azide. Reconstitute with 100 μL of sterile distilled water.

Storage and Stability

Maintain lyophilized material at 2–8°C for up to 12 months. Maintain reconstituted materialat -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H312 + H332,H412

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes.
Vaz, SH; J?rgensen, TN; Cristov?o-Ferreira, S; Duflot, S; Ribeiro, JA; Gether, U; Sebasti?o, AM
The Journal of Biological Chemistry null
Roberta Celli et al.
Current neuropharmacology, 21(1), 105-118 (2022-05-18)
Previous studies suggest that different metabotropic glutamate (mGlu) receptor subtypes are potential drug targets for treating absence epilepsy. However, no information is available on mGlu3 receptors. To examine whether (i) changes of mGlu3 receptor expression/signaling are found in the somatosensory
Roberta Celli et al.
Neuropharmacology, 178, 108240-108240 (2020-08-10)
Previous studies have shown that injection of the mGlu5 receptor positive allosteric modulator (PAM) VU0360172 into either the thalamus or somatosensory cortex markedly reduces the frequency of spike-and-wave discharges (SWDs) in the WAG/Rij model of absence epilepsy. Here we have
Elena E Bagley et al.
Neuron, 45(3), 433-445 (2005-02-08)
Adaptations in neurons of the midbrain periaqueductal gray (PAG) induced by chronic morphine treatment mediate expression of many signs of opioid withdrawal. The abnormally elevated action potential rate of opioid-sensitive PAG neurons is a likely cellular mechanism for withdrawal expression.
Jaime M Hatcher et al.
Experimental neurology, 204(2), 619-630 (2007-02-13)
Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that
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