8.53041

Boc-His(Tos)-OH

Novabiochem^®

• Synonym(s): Boc-His(Tos)-OH, N-α-t.-Boc-N-im-tosyl-L-histidine
• Empirical Formula (Hill Notation): C₁₈H₂₃N₃O₆S
• CAS Number: 35899-43-5
• Molecular Weight: 409.46
• MDL number: MFCD00065967
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥98% (TLC); ≥98.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Boc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• storage temp.: 15-25°C
• InChI: 1S/C18H23N3O6S/c1-12-5-7-14(8-6-12)28(25,26)21-10-13(19-11-21)9-15(16(22)23)20-17(24)27-18(2,3)4/h5-8,10-11,15H,9H2,1-4H3,(H,20,24)(H,22,23)/t15-/m0/s1
• InChI key: DCLJSEPKYJSEHW-HNNXBMFYSA-N

Description

General description

Standard building block for introduction of histidine amino-acid residues by Boc SPPS.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Literature references

^[1] T. Fujii, et al. (1974) Bull. Chem. Soc. Jpn., 47, 3146.
^[2] J. M. v. d. Eijk, et al. (1980) J. Org. Chem., 45, 547.

Linkage

Replaces: 04-12-0012

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in dioxan): +10.0 - +13.0 °
Purity (TLC(011B)): ≥ 98 %
Purity (TLC(011C)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (50 mg in ml EtOH): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable