The isomer ratio of product 495455 has not been determined. It is known that the total (A+B+C) is greater than or equal to 90 percent.
495455
Oligomycin
≥90% (mixture of A, B, and C isomers, HPLC), powder, Antibiotic, Calbiochem
Synonym(s):
Oligomycin
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About This Item
Empirical Formula (Hill Notation):
C45H74O11
CAS Number:
Molecular Weight:
791.06
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90% (mixture of A, B, and C isomers, HPLC)
Form:
powder
Storage condition:
OK to freeze
Pricing and availability is not currently available.
Product Name
Oligomycin, A mixture of A, B, and C isomers.
Quality Segment
assay
≥90% (mixture of A, B, and C isomers, HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
shipped in
ambient
storage temp.
−20°C
InChI
1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+
InChI key
MNULEGDCPYONBU-ZUSSGZTJSA-N
General description
A mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase, preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Membrane-bound mitochondrial ATPase (F1)
Membrane-bound mitochondrial ATPase (F1)
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Wolvetang, E.J., et al. 1994. FEBS Lett.339, 40.
Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther.264, 515.
Brustovetsky, N.N., et al. 1993. FEBS Lett.315, 233.
Nagamune, H., et al. 1993. Biochim. Biophys. Acta1141, 231.
Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther.264, 515.
Brustovetsky, N.N., et al. 1993. FEBS Lett.315, 233.
Nagamune, H., et al. 1993. Biochim. Biophys. Acta1141, 231.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
1 of 1
This Item | |
|---|---|
| description A mixture of A, B, and C isomers. | description ≥90% total oligomycins basis (HPLC) |
| form powder | form powder |
| assay ≥90% (mixture of A, B, and C isomers, HPLC) | assay ≥90% total oligomycins basis (HPLC) |
| Quality Level 100 | Quality Level 200 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - |
| storage temp. −20°C | storage temp. −20°C |
| storage condition OK to freeze | storage condition - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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Could you provide information on the proportions or ratio of Oligomycin A, B, and C in this mixture? Additionally, are the proportions consistent between lots?
1 answer-
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As for the oligomycin(495455),what solvent can I use to dissolve it in order to preserve it as long as possible?
1 answer-
Oligomycin is soluble in DMSO at 50 mg/mL, in ethanol at 250 mg/mL, and in acetone at 50 mg/mL. The solution is stable for at least a week at 0-4 °C and for several months when stored frozen in aliquots at -20 °C.
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