422689

K_ir2.1 Inhibitor, ML133

The K_ir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of K_ir2.1. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): K_ir2.1 Inhibitor, ML133, Inward rectifier potassium channel blocker, ML133
• Empirical Formula (Hill Notation): C₁₉H₁₉NO
• CAS Number: 185669-79-8
• Molecular Weight: 277.36
• MDL number: MFCD01469095
• UNSPSC Code: 12352200
• NACRES: NA.28

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 10 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: COC(C=C1)=CC=C1CNCC2=C(C=CC=C3)C3=CC=C2
• InChI: 1S/C19H19NO/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17/h2-12,20H,13-14H2,1H3
• InChI key: GIFYKGIODMXYNT-UHFFFAOYSA-N

Description

General description

A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, K_ir2.1 (IC₅₀ = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the K_ir2.x family, but has no effect on K_ir1.1 (IC₅₀ >300 µM) and displays weak activity for K_ir4.1 and K_ir7.1 (IC₅₀ = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on K_ir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lindsley, C.W., et al. 2011. ACS Chem. Biol.6, 845.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable